Endocrine Abstracts

Introduction: Diabetes insipidus (DI) is a rare pathology. The advent of hypothalamic-pituitary MRI has made it possible to make a positive diagnosis by avoiding the water restriction test (WRT). The etiological diagnosis is still a challenge in view of the diversity of diseases involved, which influences the therapeutic management and prognosis.Work Objectives: The objectives of our work were to describe the clinical, paraclinical and genetic features o...

Introduction: Pituitary stalk thickening (PST) is often identified on magnetic resonance imaging (MRI), either incidentally or during diagnostic workup of hypopituitarism. Currently, there is no unified standard for the definition of PST. As a reference, a pituitary stalk with width over 3 mm has been used as the diagnostic criterion for PST in recent years. The disease spectrum of PST is quite diverse and can be grouped into three broad categories: neoplastic, inflammatory an...

Introduction: Growth hormone (GH) treatment in congenital growth hormone deficiency (CGHD) is indicated to improve the prognosis of the statural prognosis. The aim of this study is to identify the predictive factors of a favorable response to GH therapy.Patients & Methods: This is a retrospective study, conducted over a period of 27 years, including 30 patients with CGHD treated with hormonal therapy.Results: The CGHD was diagn...

Introduction: Cardiothyreosis is the consequence of the effects of excess free thyroid hormones on the vascular wall and myocardium. This complication is the most serious aspect of hyperthyroidism. Rhythm disorders and heart failure are the most frequently noted. The prevalence of coronary insufficiency is lower. The aim of this study is to evaluate the characteristics of coronary insufficiency in patients with hyperthyroidism.Method: This is a retrospec...

Amiodarone is considered by many the most potent antiarrhythmic drug. The other side of the coin is that it’s associated with many side effects including disturbances in the thyroid function, which can be seen in 14 to 18 % of the cases (1). This case is about a 56-year-old male patient with a history of mitral valve disease who was on Amiodarone for 3 years. His personal history was notable with Epilepsy of unknow etiology for which he was on sodium valproate. During fol...

Introduction: Addison disease (AD) is associated with high risk of decreased bone mineral density (BMD) and osteoporosis. Causes are complex, including lifelong glucocorticoid replacement therapy. Several studies have pointed a significant relationship between glucocorticoid dose and low BMD in patients with AD. The aim of our study is to assess the impact of glucocorticoid replacement dose on BMD among Tunisian patients with AD.Patients and Methods: We ...

Introduction: Inappropriate glucocorticoid replacement therapy results in higher mortality rates in patients with Addison disease (AD), predominantly due to higher prevalence of cardiovascular diseases, disturbed glycometabolic state and altered anthropometric parameters. The aim of this study was to assess the impact of life-long corticosteroid exposure on anthropometric parameters in patients with AD.Patients and Methods: This Tunisian cross-sectional ...

Introduction: Glucocorticoid replacement therapy may result in long-term morbidities, including cardiovascular diseases which can increase cardiovascular risk. The study was aimed to assess the impact of life-long glucocorticoid replacement therapy on cardiovascular parameters in patients with Addison disease (AD).Patients and Methods: This cross-sectional study was conducted assess cardiovascular events in patients followed for AD for at least 5 years, ...

Objective: To describe the clinical and biological presentation of acute pancreatitis (AP) and diabetic ketoacidosis (DKA) in type 1 diabetes (T1D).Patients and Methods: A retrospective descriptive study of 10 T1DM patients with simultaneous DKA and AP.Results: The mean age at diagnosis of T1DM was 19.7±9.3 years with a female predominance (60%). T1DM was frequently inaugurated by a cardinal syndrome (50%) or spontaneous DKA (20...

Background and aims: Pituitary adenomas (PA) are small, generally benign tumors found in the pituitary gland. PA in men are rare However, they are characterized by the frequency of invasive and aggressive tumours, which makes their management difficult. The aim of this study is to clarify radiological characteristics of pituitary adenomas in men. Materials and methods: Retrospective descriptive study of 80 adult men with PA, hospitalized in the endocrinology department from 19...